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FREE RADICALS IN BIOLOGY AND MEDICINE (3RD ED)

ISBN: 9780198500445
Barry Halliwell, John Gutteridge  Halliwell (medical biochemistry, King's College, London) and Gutteridge (pharmacology, King's College) direct their discussion primarily to biologists and clinicians, and assume virtually no knowledge of chemistry. Their goal is to lead readers gently into an understanding of what free radicals are, how they are generated, and how they can react. Then they evaluate the role of radical reactions in several biological systems. The first edition appeared in 1985, and the 1989 second edition is here updated with the extensive information provided by modern techniques of molecular, cellular, and structural biology. They also cite at least one reference for each finding. Oxygen is a toxic gas - an introduction to oxygen toxicity and reactive species p. 1 The chemistry of free radicals and related 'reactive species' p. 30 Antioxidant defences : endogenous and diet derived p. 79 Cellular responses to oxidative stress : adaptation, damage, repair, senescence and death p. 187 Measurement of reactive species p. 268 Reactive species can pose special problems needing special solutions : some examples p. 341 Reactive species can be useful : some more examples p. 395 Reactive species can be poisonous : their role in toxicology p. 440 Reactive species and disease : fact, fiction or filibuster? p. 488 Ageing, nutrition, disease and therapy : a role for antioxidants? p. 614 Some basic chemistry p. 678 Table of Contents provided by Blackwell.